Barclays is cutting around 5,000 staff as it introduces more artificial intelligence (AI) into its processes.
The banking group said 1,000 posts had already been closed and it expects a further reduction of 4,000 to be complete by the end of this year.
The cuts amount to 5% of its global workforce with most of them among operational and functional roles.
Barclays said the cuts were the result of investments in technology, with AI making some work processes more efficient.
The banking group is reaching the end of a three year cost-cutting programme focused primarily on its UK retail banking arm, although the investment banking division is also affected.