Marston's Brewery, its history and legacy in the town were "iconic", Carlsberg Britvic said
Marston's Brewery could close in Burton-upon-Trent, under plans revealed by its owners.
Carlsberg Britvic said it was proposing to shut the facility together with its primary logistics operation based at that site next summer. About 310 people are affected.
Burton-upon-Trent's connections with the brewing industry date back centuries, with the firm describing its own history and legacy in the town as "iconic".
However, it said the "stark reality" was that UK cask ale volumes had more than halved in less than a decade and "this trend looks set to continue across the UK".