Jensen Huang is not the first CEO to leave a company he helped build.
But experts told CNBC that his sudden resignation from Nvidia at a critical juncture is unique and leaves his eventual successor with challenges in leading the company that's powering the artificial intelligence boom.
In 33 years, Huang, who resigned on Thursday amid reports of extramarital affairs, including with a woman U.S. intelligence believes is a spy for China, made the company he co-founded the world's most valuable.
Former Goldman Sachs CEO Lloyd Blankfein wrote on X that he was "indispensable" but "the graveyards are filled with indispensable men," referencing a quote attributed to French leader Charles de Gaulle.
While the board looks for a new CEO and CFO Colette Kress does the job temporarily; analysts say Huang's charisma and bullish drive will be hard to replicate.